TGF-alpha (Animal Free)
TGF-α is an EGF-related polypeptide growth factor that signals through the EGF receptor, and stimulates the proliferation of a wide range of epidermal and epithelial cells. It is produced by monocytes, keratinocytes, and various tumor cells. TGF-α induces anchorage-independent transformation in cultured cells. Human, murine and rat TGF-α are cross-species reactive. Recombinant Human TGF-α is a 50 amino acid polypeptide (5.5 kDa), which shares approximately 40% sequence homology with EGF, including 6 conserved cysteine residues, which form 3 intramolecular disulfide bonds.
Product Specifications
Synonyms
TGFA; TFGA
NCBI Gene ID
7039
UniProt
P01135
Accession Number
NP_003227.1
Accession Number mRNA
NM_003236
Chromosomal Location
2p13
Reactivity
Human
Cross Reactivity
Chicken, Horse, Human, Mouse, Rat
Sequence
VVSHFNDCPD SHTQFCFHGT CRFLVQEDKP ACVCHSGYVG ARCEHADLLA
Endotoxin
< 0.01 ng/µg of protein (< 0.1 EU/µg)
Purity
≥ 98% by SDS-PAGE gel and HPLC analyses.
Bioactivity
Length
50
Form
Lyophilized
Molecular Weight
5.5 kDa
Host or Source
E. coli
Frequently Asked Questions
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