TGF-alpha
TGF-α is an EGF-related polypeptide growth factor that signals through the EGF receptor, and stimulates the proliferation of a wide range of epidermal and epithelial cells. It is produced by monocytes, keratinocytes, and various tumor cells. TGF-α induces transformation anchorage independence in cultured cells. Human, murine and rat TGF-α are cross-species reactive. Recombinant human TGF-α is a 50 amino acid polypeptide (5.5 kDa) which shares approximately 40% sequence homology with EGF, including 6 conserved cysteine residues, which form 3 intramolecular disulfide bonds.
Product Specifications
Synonyms
TGFA; TFGA
NCBI Gene ID
7039
UniProt
P01135
Accession Number
NP_003227.1
Accession Number mRNA
NM_003236
Chromosomal Location
2p13
Reactivity
Human
Cross Reactivity
Chicken, Mouse, Rat, Human, Horse
Sequence
VVSHFNDCPD SHTQFCFHGT CRFLVQEDKP ACVCHSGYVG ARCEHADLLA
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Length
50
Form
Lyophilized
Molecular Weight
5.5 kDa
Host or Source
E. coli
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
