TFF-1
The Trefoil Factor peptides (TFF1, TFF2 and TFF3) are expressed in the gastrointestinal tract, and appear to play an important role in intestinal mucosal defense and repair. TFF1 is essential for normal differentiation of the antral and pyloric gastric mucosa and functions as a gastric-specific tumor suppressor gene. Recombinant human TFF1 is a 13.2 kDa homodimeric protein consisting of two 60 amino acid polypeptide chains, which includes a 40-amino acid trefoil motif containing three conserved intramolecular disulfide bonds.
Product Specifications
Synonyms
TFF1; pS2; BCEI; HPS2; HP1.A; pNR-2; D21S21
NCBI Gene ID
7031
UniProt
P04155
Accession Number
NP_003216.1
Accession Number mRNA
NM_003225
Chromosomal Location
21q22.3
Reactivity
Human
Cross Reactivity
Human
Sequence
EAQTETCTVA PRERQNCGFP GVTPSQCANK GCCFDDTVRG VPWCFYPNTI DVPPEEECEF
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to chemoattract human MCF-7 cells using a concentration 5-10 μg/ml.
Length
60
Form
Lyophilized
Molecular Weight
6.7 kDa
Host or Source
E. coli
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