TACI (TNFRSF13B)
TACI, a member of the TNF Receptor superfamily, is expressed in the small intestine, spleen, thymus, peripheral blood leukocytes, activated T cells, and resting B cells. TACI binds to both APRIL and BAFF and can stimulate the activation of transcription factors; NF-kappaB, AP-1, and mediates calcineurin dependent activation of NF-AT (nuclear-factor of activated T cells) . TACI also plays a key role in the stimulation of B and T cell function. Soluble TACI inhibits APRIL-stimulated proliferation of primary B-cells by blocking the binding of APRIL to the membrane anchored TACI receptor. Recombinant human TACI is a soluble 160 amino acid polypeptide (17.8 kDa) comprising the TNFR homologous cysteine rich extracellular domain of the TACI protein.
Product Specifications
Synonyms
TNFRSF13B; CVID; TACI; CD267; CVID2; TNFRSF14B
NCBI Gene ID
23495
UniProt
O14836
Accession Number
NP_036584.1
Accession Number mRNA
NM_012452.2
Chromosomal Location
17p11.2
Reactivity
Human
Cross Reactivity
Human
Sequence
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to block human BAFF induced T2B cell survival using a concentration range of 1.0-3.0 µg/ml.
Length
160
Form
Lyophilized
Molecular Weight
17.8 kDa
Host or Source
E. coli
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