SDF-1 beta (CXCL12)
SDF-1α and β are stromal derived CXC chemokines, and signal through the CXCR4 receptor. SDF-1α and β chemoattract B and T cells, and have been shown to induce migration of CD34+ stem cells. Additionally, the SDF-1 proteins exert HIV suppressive activity in cells expressing the CXCR4 receptor. Recombinant murine SDF-1β is a 8.5 kDa protein containing 72 amino acid residues.
Product Specifications
Synonyms
Pxorf31
NCBI Gene ID
912189
UniProt
P40224
Accession Number
NP_068350.1
Accession Number mRNA
NM_021704
Chromosomal Location
6 F1; 6 53.0 cM
Reactivity
Mouse
Cross Reactivity
Human, Mouse
Sequence
KPVSLSYRCP CRFFESHIAR ANVKHLKILN TPNCALQIVA RLKNNNRQVC IDPKLKWIQE YLEKALNKRL KM
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to chemoattract human monocytes using a concentration range of 50.0-100.0 ng/ml.
Length
72
Form
Lyophilized
Molecular Weight
8.5 kDa
Host or Source
E. coli
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