SDF-1 alpha (CXCL12, Animal Free)
SDF-1α and β are stromal-derived, CXC chemokines that signal through the CXCR4 receptor. SDF-1α and β chemoattract B and T cells, and have been shown to induce migration of CD34+ stem cells. Additionally, the SDF-1 proteins exert HIV-suppressive activity in cells expressing the CXCR4 receptor. Human and murine SDF-1 proteins act across species. SDF-1α and β contain the four highly conserved cysteine residues present in CXC chemokines. The mature SDF-1α protein is the result of alternative splicing of the SDF-1 gene and contains 68 amino acid residues. Recombinant Human SDF-1α is an 8.0 kDa protein containing 68 amino acid residues.
Product Specifications
Synonyms
CXCL12; IRH; PBSF; SDF1; TLSF; SDF1A; SDF1B; TPAR1; SCYB12
NCBI Gene ID
6387
UniProt
P48061
Accession Number
NP_954637.1
Accession Number mRNA
NM_199168.3
Chromosomal Location
10q11.1
Reactivity
Human
Cross Reactivity
Human, Mouse
Sequence
KPVSLSYRCP CRFFESHVAR ANVKHLKILN TPNCALQIVA RLKNNNRQVC IDPKLKWIQE YLEKALNK
Endotoxin
< 0.01 ng/µg of protein (< 0.1 EU/µg)
Purity
≥ 98% by SDS-PAGE gel and HPLC analyses.
Bioactivity
Determined by its ability to chemoattract IL-2-activated human T cells using a concentration range of 20.0-80.0 ng/ml.
Length
68
Form
Lyophilized
Molecular Weight
8.0 kDa
Host or Source
E. coli
Frequently Asked Questions
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