SDF-1 alpha (CXCL12)
SDF-1α and β are stromal derived CXC chemokines, and signal through the CXCR4 receptor. SDF-1α and β chemoattract B and T cells, and have been shown to induce migration of CD34+ stem cells. Additionally, the SDF-1 proteins exert HIV suppressive activity in cells expressing the CXCR4 receptor. Recombinant murine SDF-1α is a 7.9 kDa protein containing 68 amino acid residues.
Product Specifications
Synonyms
Pxorf31
NCBI Gene ID
912189
UniProt
P40224
Accession Number
NP_068350.1
Accession Number mRNA
NM_021704
Chromosomal Location
6 F1; 6 53.0 cM
Reactivity
Mouse
Cross Reactivity
Human, Rat, Mouse, Leech
Sequence
KPVSLSYRCP CRFFESHIAR ANVKHLKILN TPNCALQIVA RLKNNNRQVC IDPKLKWIQE YLEKALNK
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to chemoattract human peripheral blood monocytes using a concentration of 50-100 ng/ml.
Length
68
Form
Lyophilized
Molecular Weight
7.9 kDa
Host or Source
E. coli
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