SCGF-alpha
Stem Cell Growth Factor-alpha (SCGF-alpha) is a newly discovered hematopoietic growth factor that exerts its activity at the early stages of hematopoiesis. Human SCGF-alpha is a non-glycosilated species-specific cytokine that can support growth of primitive hematopoietic cells, and in combination of EPO or GM-CSF, it promotes proliferation of erythroid and myeloid progenitors, respectively. Recombinant human SCGF-alpha is a 33.9 kDa polypeptide containing 305 amino acid residues.
Product Specifications
Synonyms
CLEC11A; P47; SCGF; LSLCL; CLECSF3
NCBI Gene ID
6320
UniProt
Q9Y240
Accession Number
NP_002966.1
Accession Number mRNA
NM_002975.2
Chromosomal Location
19q13.3
Reactivity
Human
Cross Reactivity
Human
Sequence
GHGARGAERE WEGGWGGAQE EEREREALML KHLQEALGLP AGRGDENPAG TVEGKEDWEM EEDQGEEEEE EATPTPSSGP SPSPTPEDIV TYILGRLAGL DAGLHQLHVR LHALDTRVVE LTQGLRQLRN AAGDTRDAVQ ALQEAQGRAE REHGRLEGCL KGLRLGHKCF LLSRDFEAQA AAQARCTARG GSLAQPADRQ QMEALTRYLR AALAPYNWPV WLGVHDRRAE GLYLFENGQR VSFFAWHRSP RPELGAQPSA SPHPLSPDQP NGGTLENCVA QASDDGSWWD HDCQRRLYYV CEFPF
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its inhibitory effect on the proliferation of TF-1 cells previously grown in media containing GM-CSF. The ED50 for this effect was observed at 2.5 ng/ml.
Length
305
Form
Lyophilized
Molecular Weight
33.9 kDa
Host or Source
E. coli
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