SCF
Stem Cell Factor (SCF) is a hematopoietic growth factor that exerts its activity by signaling through the c-Kit receptor. SCF and c-Kit are essential for the survival, proliferation and differentiation of hematopoietic cells committed to the melanocyte and germ cell lineages. Human SCF manifests low activity on murine cells, while murine and rat SCF are fully active on human cells. Recombinant rat SCF is an 18.4 kDa polypeptide containing 165 amino acid residues, which corresponds to the sequence of the secreted soluble form of SCF.
Product Specifications
Synonyms
Kitlg; Mgf; SCF; Kitl
NCBI Gene ID
60427
UniProt
P21581
Accession Number
NP_068615.1
Accession Number mRNA
NM_021843
Chromosomal Location
7Q13
Reactivity
Rat
Cross Reactivity
Human, Mouse
Sequence
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by the dose-dependent stimulation of the proliferation of the human TF-1 cells. The expected ED50 for this effect is 20 - 40 ng/ml.
Length
165
Form
Lyophilized
Molecular Weight
18.4 kDa
Host or Source
E. coli
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