R-Spondin-1
R-Spondin-1 (Rspo-1) belongs to the (Rspo) family of Wnt modulators. Currently, the family consists of four structurally related secreted ligands (Rspo 1-4), all containing the furin-like and thrombospondin structural domains. Rspo-1 is expressed in certain areas of the developing central nervous system, as well as in the adrenal glands, ovary, testis, thyroid, and trachea. Rspo can interact with the Frizzled/LRP6 receptor complex in a manner that stimulates the Wnt/beta-catenin signaling pathway. Recombinant Murine R-Spondin-1 is a 27.1 kDa protein consisting of 245 amino acid residues. Due to glycosylation, R-Spondin-1 migrates at an apparent molecular weight of approximately 40.0 kDa by SDS-PAGE analysis under reducing conditions.
Product Specifications
Synonyms
Roof plate-specific Spondin-1, RSPO1
NCBI Gene ID
192199
UniProt
Q9Z132
Accession Number
NP_619624.2
Accession Number mRNA
NM_138683.2
Reactivity
Mouse
Cross Reactivity
Mouse
Sequence
Assay Protocol
Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml. Do not vortex.
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 95% by SDS-PAGE & HPLC analyses
Bioactivity
R-Spondin-1 enhances BMP-2-mediated differentiation of MC3T3-E1 cells.
Length
245
Form
Lyophilized
Buffer
10mM Sodium Phosphate, pH 7.5 and 150mM NaCl
Reconstitution
Water
Molecular Weight
40.0 kDa
Host or Source
CHO cells
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