RANTES (CCL 5)
RANTES is a CC-chemokine that can signal through the CCR1, CCR3, CCR5 and US28 (cytomegalovirus receptor) receptors. It is a chemoattractant towards monocytes, memory T cells (CD4+/CD45RO), basophils, and eosinophils. RANTES also has the capability to inhibit certain strains of HIV-1, HIV-2 and simian immunodeficiency virus (SIV) . Recombinant murine RANTES is a 7.8 kDa protein containing 68 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.
Product Specifications
Synonyms
Ccl5; SISd; Scya5; RANTES; TCP228; MuRantes
NCBI Gene ID
20304
UniProt
P30882
Accession Number
NP_038681.2
Accession Number mRNA
NM_013653.3
Chromosomal Location
11 C; 11 47.4 cM
Reactivity
Mouse
Cross Reactivity
Rat, Mouse, Leech, Human, Bacteria
Sequence
SPYGSDTTPC CFAYLSLALP RAHVKEYFYT SSKCSNLAVV FVTRRNRQVC ANPEKKWVQE YINYLEMS
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Length
68
Form
Lyophilized
Molecular Weight
7.8 kDa
Host or Source
E. coli
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