RANTES (CCL 5)

RANTES is a CC-chemokine that can signal through the CCR1, CCR3, CCR5 and US28 (cytomegalovirus receptor) receptors. It is a chemoattractant towards monocytes, memory T cells (CD4+/CD45RO), basophils, and eosinophils. RANTES also has the capability to inhibit certain strains of HIV-1, HIV-2 and simian immunodeficiency virus (SIV) . Recombinant murine RANTES is a 7.8 kDa protein containing 68 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.

Product Specifications

Synonyms

Ccl5; SISd; Scya5; RANTES; TCP228; MuRantes

NCBI Gene ID

20304

UniProt

P30882

Accession Number

NP_038681.2

Accession Number mRNA

NM_013653.3

Chromosomal Location

11 C; 11 47.4 cM

Reactivity

Mouse

Cross Reactivity

Rat, Mouse, Leech, Human, Bacteria

Sequence

SPYGSDTTPC CFAYLSLALP RAHVKEYFYT SSKCSNLAVV FVTRRNRQVC ANPEKKWVQE YINYLEMS

Endotoxin

< 0.1 ng/µg of protein (< 1EU/µg)

Purity

> 98% by SDS-PAGE & HPLC analyses

Bioactivity

Determined by its ability to chemoattract total human lymphocyte population and total murine T cell population using a concentration range of 1.0-10.0 ng/ml.