RANTES (CCL 5)
RANTES is a CC-chemokine that can signal through the CCR1, CCR3, CCR5 and US28 (cytomegalovirus receptor) receptors. It is a chemoattractant towards monocytes, memory T cells (CD4+/CD45RO), basophils, and eosinophils. RANTES also has the capability to inhibit certain strains of HIV-1, HIV-2 and simian immunodeficiency virus (SIV) . Recombinant human RANTES is a 7.8 kDa protein containing 68 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.
Product Specifications
Synonyms
CCL5; SISd; SCYA5; RANTES; TCP228; D17S136E
NCBI Gene ID
6352
UniProt
P13501
Accession Number
NP_002976.2
Accession Number mRNA
NM_002985
Chromosomal Location
17q11.2-q12
Reactivity
Human
Cross Reactivity
Cow, Hamster, Monkey, Mouse, Rat, Human, Leech, Bacteria
Sequence
SPYSSDTTPC CFAYIARPLP RAHIKEYFYT SGKCSNPAVV FVTRKNRQVC ANPEKKWVRE YINSLEMS
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to chemoattract human blood monocytes using a concentration range of 1.0-10.0 ng/ml.
Length
68
Form
Lyophilized
Molecular Weight
7.8 kDa
Host or Source
E. coli
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