Prokineticin-2
Prokineticin-2 (PK2) is a cysteine-rich secreted protein that is expressed in the testis and in lower levels of the small intestine. PK2 regulates various biological functions including gastrointestinal motility, angiogenesis and circadiam rhythms. It is closely related to EG-VEGF (Prokineticin-1) and binds to two orphan B-protein-coupled receptors termed PK-R1 and PK-R2. Recombinant human Prokineticin-2 is an 8.8 kDa protein consisting of 81 amino acid residues and ten cysteine residues that potentially form five pairs of intra-molecular disulfide bonds.
Product Specifications
Synonyms
PROK2
NCBI Gene ID
60675
UniProt
Q9HC23
Accession Number
NP_068754.1
Accession Number mRNA
NM_021935.3
Chromosomal Location
3p13
Reactivity
Human
Cross Reactivity
Mouse, Rat, Human
Sequence
AVITGACDKD SQCGGGMCCA VSIWVKSIRI CTPMGKLGDS CHPLTRKVPF FGRRMHHTCP CLPGLACLRT SFNRFICLAQ K
Assay Protocol
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Data not available.
Length
81
Form
Lyophilized
Molecular Weight
8.8 kDa
Storage Conditions
Host or Source
E. coli
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