PF-4 (CXCL4)
PF-4 is a CXC chemokine that is expressed in megakaryocytes and stored in the α-granules of platelets. PF-4 is chemotactic towards neutrophils and monocytes and has been shown to inhibit angiogenesis. Recombinant human PF-4 is a 7.8 kDa protein containing 70 amino acid residues, including the four highly conserved residues present in CXC chemokines.
Product Specifications
Synonyms
PF4; PF-4; CXCL4; SCYB4
NCBI Gene ID
5196
UniProt
P02776
Accession Number
NP_002610.1
Accession Number mRNA
NM_002619.2
Chromosomal Location
4q12-q21
Reactivity
Human
Cross Reactivity
Mouse, Trout, Human, Bacteria
Sequence
EAEEDGDLQC LCVKTTSQVR PRHITSLEVI KAGPHCPTAQ LIATLKNGRK ICLDLQAPLY KKIIKKLLES
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to chemoattract human fibroblasts using a concentration range of 1.0-10.0 ng/ml.
Length
70
Form
Lyophilized
Molecular Weight
7.8 kDa
Host or Source
E. coli
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