Osteoprotegerin (OPG)
Osteoprotegerin (OPG) is a member of the TNFR superfamily that can act as a decoy receptor for RANKL. Binding of soluble OPG to sRANKL inhibits osteoclastogenesis by interrupting the signaling between stromal cells and osteoclastic progenitor cells, thereby leading to excess accumulation of bone and cartilage. OPG is expressed in a wide variety of tissues including adult heart, lung, kidney, liver, spleen, prostate, lymph node and bone marrow. OPG is secreted both as a monomeric and a dimeric protein. Its primary structure consists of seven distinct domains, four of which corresponds to the extracellular cysteine-rich domains of TNFR proteins and constitutes the soluble OPG. Recombinant human OPG is a soluble 20.0 kDa protein containing 174 amino acid residues.
Product Specifications
Synonyms
TNFRSF11B; OPG; TR1; OCIF
NCBI Gene ID
4982
UniProt
O00300
Accession Number
NP_002537.3
Accession Number mRNA
NM_002546.3
Chromosomal Location
8q24
Reactivity
Human
Cross Reactivity
Mouse, Rat, Human
Sequence
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to neutralize the stimulation of U937 cells treated with 10 ng/ml of soluble RANKL (sRANKL) .
Length
174
Form
Lyophilized
Molecular Weight
20 kDa
Host or Source
E. coli
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