NT-3 (Animal Free)
NT-3 is a neurotrophic factor structurally related to β-NGF, BDNF, and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. NT-3 is expressed by neurons of the central nervous system, and can signal through the trk receptors. NT-3 promotes the growth and survival of nerve and glial cells. The amino acid sequences of human, murine and rat NT-3 are identical. Recombinant Human NT-3 is a noncovalently linked homodimer of two 13.6 kDa polypeptide monomers (240 total amino acid residues) .
Product Specifications
Synonyms
NTF3; NT3; HDNF; NGF2; NGF-2
NCBI Gene ID
4908
UniProt
P20783
Accession Number
NP_001096124.1
Accession Number mRNA
NM_001102654
Chromosomal Location
12p13
Reactivity
Human
Cross Reactivity
Human, Mouse, Rat
Endotoxin
< 0.01 ng/µg of protein (< 0.1 EU/µg)
Purity
≥ 98% by SDS-PAGE gel and HPLC analyses.
Bioactivity
Determined by its ability to bind recombinant human TrkB Fc Chimera in a functional ELISA.
Form
Lyophilized
Host or Source
E. coli
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