NT-3
NT-3 is a neurotrophic factor structurally related to β-NGF, BDNF, and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. NT-3 is expressed by neurons of the central nervous systems and can signal through the trk receptors. NT-3 promotes the growth and survival of nerve and glial cells. The amino acid sequences of human, murine and rat NT-3 are identical. Recombinant human NT-3 is a noncovalently linked homodimer, of two 13.6 kDa polypeptide monomers (240 total amino acid residues) . Human and Mouse NT-3 sequences are identical
Product Specifications
Synonyms
NTF3; NT3; HDNF; NGF2; NGF-2
NCBI Gene ID
4908
UniProt
P20783
Accession Number
NP_001096124.1
Accession Number mRNA
NM_001102654
Chromosomal Location
12p13
Reactivity
Human
Cross Reactivity
Chicken, Cow, Dog, Frog, Hamster, Mouse, Pig, Rat Human, Monkey
Sequence
MYAEHKSHRG EYSVCDSESL WVTDKSSAID IRGHQVTVLG EIKTGNSPVK QYFYETRCKE ARPVKNGCRG IDDKHWNSQC KTSQTYVRAL TSENNKLVGW RWIRIDTSCV CALSRKIGRT
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to bind recombinant human TrkB Fc Chimera in a functional ELISA.
Length
120
Form
Lyophilized
Molecular Weight
13.6 kDa
Host or Source
E. coli
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