NP-1 (alpha-Defensin 1)
Defensins (α and β) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The α-defensins which include NP-1, NP-2 and NP-3, are distinguished from the β-defensins by the pairing of their three disulfide bonds. In addition to antimicrobial activity, NP-1 exhibits chemotactic activity on dendritic cells. NP-1 is expressed as the C-terminal portion of an inactive precursor protein, which also contains a 19 amino acid N-terminal signal sequence and a 45 amino acid polypeptide. NP-1 contains a six-cysteine motif that forms three intra-molecular disulfide bonds. Recombinant human NP-1 is a 3.4 kDa protein containing 30 amino acid residues.
Product Specifications
Synonyms
Neutrophil Peptide-1, alpha Defensin-1, HNP-1, Cryptdin
NCBI Gene ID
8829
UniProt
Q15818
Accession Number
NP_002513.2
Accession Number mRNA
NM_002522.3
Chromosomal Location
10p12
Reactivity
Human
Cross Reactivity
Human
Sequence
ACYCRIPACI AGERRYGYCI YQGRLWAFCC
Assay Protocol
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to chemoattract immature dendritic cells using a concentration of 1.0-10.0 ng/ml.
Length
30
Form
Lyophilized
Molecular Weight
3.4 kDa
Storage Conditions
Host or Source
E. coli
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