NNT-1/BCSF-3
NNT-1/BCSF-3 is a neurotrophic factor with B-cell stimulating capabilities. Expressed in lymph nodes and spleen, NNT-1/BCSF-3 binds and activates glycoprotein 130 (gp130) and leukemia inhibitory factor receptor member beta (LIFR-beta) and induces tyrosine phosphorylation of these receptors. In vitro, it supports the survival of chick embryo motor and sympathetic neurons. In mice, NNT-1/BCSF-3 induces serum amyloid A, causes body weight loss and B cell hyperplasia associated with increased in serum IgG and IgM. Recombinant human NNT-1/BCSF-3 is a 22.4 kDa protein containing 199 amino acid residues.
Product Specifications
Synonyms
CLCF1; CLC; NR6; BSF3; NNT1; BSF-3; CISS2; NNT-1
NCBI Gene ID
23529
UniProt
Q9UBD9
Accession Number
NP_037378.1
Accession Number mRNA
NM_013246
Chromosomal Location
11q13.3
Reactivity
Human
Cross Reactivity
Chicken
Sequence
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
NT-1/BCSF-3 weakly supports chick E8 DRG neurite outgrowth at a concentration of 1.0 ng/ml.
Length
199
Form
Lyophilized
Molecular Weight
22.4 kDa
Host or Source
E. coli
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