NGF-beta
Β-NGF is a neurotrophic factor structurally related to BDNF, NT-3 and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. β-NGF is a potent neurotrophic factor that signals through its receptor β-NGFR, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems. β-NGF also acts as a growth and differentiation factor for B lymphocytes and enhances B-cell survival. The functional form of murine β-NGF is a noncovalently disulfide-linked homodimer, of two 13.4 kDa polypeptide monomers (240 total amino acid residues) . The three disulfide bonds are required for biological activity.
Product Specifications
Synonyms
Ngf; Ngfb
NCBI Gene ID
18049
UniProt
P01139
Accession Number
NP_038637.1
Accession Number mRNA
NM_013609
Chromosomal Location
3 F2.2; 3 48.5 cM
Reactivity
Mouse
Cross Reactivity
Human, Mouse
Sequence
SSTHPVFHMG EFSVCDSVSV WVGDKTTATD IKGKEVTVLA EVNINNSVFR QYFFETKCRA SNPVESGCRG IDSKHWNSYC TTTHTFVKAL TTDEKQAAWR FIRIDTACVC VLSRKATRRG
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analysis
Bioactivity
Length
240
Form
Lyophilized
Molecular Weight
13.4 kDa
Host or Source
E. coli
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