What is the catalog number for NGF-beta?

The catalog number for NGF-beta is M10-123-L250.

What sizes are available for NGF-beta?

NGF-beta is available in the following size(s): 100 µg.

Is NGF-beta in stock?

NGF-beta is currently made to order / not held in immediate stock. Contact us for lead time.

NGF-beta

Β-NGF is a neurotrophic factor structurally related to BDNF, NT-3 and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. β-NGF is a potent neurotrophic factor that signals through its receptor β-NGFR, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems. β-NGF also acts as a growth and differentiation factor for B lymphocytes and enhances B-cell survival. The functional form of murine β-NGF is a noncovalently disulfide-linked homodimer, of two 13.4 kDa polypeptide monomers (240 total amino acid residues) . The three disulfide bonds are required for biological activity.

Product Specifications

Synonyms

Ngf; Ngfb

NCBI Gene ID

18049

UniProt

P01139

Accession Number

NP_038637.1

Accession Number mRNA

NM_013609

Chromosomal Location

3 F2.2; 3 48.5 cM

Reactivity

Mouse

Cross Reactivity

Human, Mouse

Sequence

SSTHPVFHMG EFSVCDSVSV WVGDKTTATD IKGKEVTVLA EVNINNSVFR QYFFETKCRA SNPVESGCRG IDSKHWNSYC TTTHTFVKAL TTDEKQAAWR FIRIDTACVC VLSRKATRRG

Endotoxin

< 0.1 ng/µg of protein (< 1EU/µg)

Purity

> 98% by SDS-PAGE & HPLC analysis

Bioactivity

The ED50 as determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg.