NAP-2 (CXCL7)
NAP-2 is a CXC chemokine that can signal through the CXCR1 and CXCR2 receptors. It is produced in leukocytes by enzymatic processing of a precursor called platelet basic protein (PBP) . NAP-2 chemoattracts and activates neutrophils. Recombinant human NAP-2 protein is a 7.6 kDa protein containing 70 amino acid residues including the four highly conserved cysteine residues present in CXC chemokines, and also including the ELR motif common to CXC chemokines that bind to CXCR1 and CXCR2.
Product Specifications
Synonyms
CXCL7, NAP1L4; NAP2; NAP2L; hNAP2; NAP1L4b
NCBI Gene ID
5473
UniProt
P02775
Accession Number
NP_002695.1
Accession Number mRNA
NM_002704.3
Chromosomal Location
5 E1; 5
Reactivity
Human
Cross Reactivity
Hamster, Human, Mouse
Sequence
AELRCMCIKT TSGIHPKNIQ SLEVIGKGTH CNQVEVIATL KDGRKICLDP DAPRIKKIVQ KKLAGDESA
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analysis
Bioactivity
Determined by its ability to chemoattract human neutrophils using a concentration range of 1.0-10.0 ng/ml.
Length
70
Form
Lyophilized
Molecular Weight
7.6 kDa
Host or Source
E. coli
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