MSLN / Mesothelin Protein (hFc Tag)
The megakaryocyte potentiating factor belongs to the mesothelin family. This family is comprised of several mammalian pre-pro-megakaryocyte potentiating factor precursor (MPF) or mesothelin proteins. Mesothelin is a glycosylphosphatidylinositol-linked glycoprotein highly expressed in mesothelial cells, mesotheliomas, and ovarian cancer, but the biological function of the protein is not known. Megakaryocyte potentiating factor is highly expressed in mesotheliomas, ovarian cancers, and some squamous cell carcinomas (at protein level) . It interacts with MUC16 and potentiates megakaryocyte colony formation in vitro. Megakaryocyte potentiating factor is secreted by several mesothelioma cell lines and is frequently elevated in the blood of patients with mesothelioma. Measurement of this protein may be useful in following the response of mesothelioma to treatment.
Product Specifications
Synonyms
CAK1 Protein; MPF Protein; SMRP Protein
Accession Number
Q13421-2
Reactivity
Human
Cross Reactivity
Human
Label
HFc-Tag
Assay Protocol
See Datasheet send with the product
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
Purity
> 95 % as determined by SDS-PAGE
Bioactivity
Data not available
Length
491
Form
Lyophilized
Buffer
PBS, pH 7.4
Reconstitution
See Datasheet
Molecular Weight
56 kDa
Storage Conditions
Host or Source
HEK 293 cells
Frequently Asked Questions
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