MIG (CXCL9)
MIG, a CXC chemokine, is produced by IFN stimulated monocytes, macrophages and endothelial cells. It signals through the CXCR3 receptor. MIG selectively chemoattracts Th1 lymphocytes, and also exerts other activities including inhibition of tumor growth, angiogenesis, and inhibition of colony formation of hematopoietic progenitors. Human MIG is active on murine cells. Recombinant murine MIG is a 12.2 kDa protein containing 105 amino acid residues, including the four highly conserved cysteine residues present in CXC chemokines
Product Specifications
Synonyms
Cxcl9; CMK; Mig; MuMIG; Scyb9; crg-10; BB139920
NCBI Gene ID
17329
UniProt
P18340
Accession Number
NP_032625.2
Accession Number mRNA
NM_008599.4
Chromosomal Location
5 E2; 5 53.0 cM
Reactivity
Mouse
Cross Reactivity
Human, Mouse, Monkey, Leech, Rat
Sequence
TLVIRNARCS CISTSRGTIH YKSLKDLKQF APSPNCNKTE IIATLKNGDQ TCLDPDSANV KKLMKEWEKK INQKKKQKRG KKHQKNMKNR KPKTPQSRRR SRKTT
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to chemoacttract human lymphocytes using a concentration range of 0.1-1.0 ng/ml.
Length
105
Form
Lyophilized
Molecular Weight
12.2 kDa
Host or Source
E. coli
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