Midkine
Midkine and its functionally-related protein Pleiotrophin are heparin-binding neurotrophic factors that signal through the same receptor, known as anaplastic lymphoma kinase (ALK) . MK plays an important regulatory role in epithelial-mesenchymal interactions during fetal development and in postnatal lung development. MK chemoattracts embryonic neurons, neutrophils and macrophages, and by signaling through the ALK receptor it exerts angiogenic, growth and survival activities during tumorgenesis. Recombinant murine Midkine is a 13.4 kDa protein containing 121 amino acid residues including five intra-molecular disulfide bonds.
Product Specifications
Synonyms
Mdk; MK; Mek
NCBI Gene ID
17242
UniProt
P12025
Accession Number
NP_034914.1
Accession Number mRNA
NM_010784.4
Chromosomal Location
2 E1; 2 53.0 cM
Reactivity
Mouse
Cross Reactivity
Mouse
Sequence
VAKKKEKVKK GSECSEWTWG PCTPSSKDCG MGFREGTCGA QTQRVHCKVP CNWKKEFGAD CKYKFESWGA CDGSTGTKAR QGTLKKARYN AQCQETIRVT KPCTSKTKSK TKAKKGKGKD
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to chemoattract human neutrophils using a concentration range of 10-100 ng/ml.
Length
120
Form
Lyophilized
Molecular Weight
13.3 kDa
Host or Source
E. coli
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