MIA-2 (Melanoma inhibitory activity 2)

MIA2 is a secreted cytokine and a member of the MIA/OTOR family. Members of this family which also includes MIA, OTOR, and TANGO share a Src homology-3 (SH3) -like domain. MIA2 is predominantly expressed in hepatocytes. Elevated levels of MIA2 may represent a clinically useful marker for diagnosis of hepatic disease activity and severity. Recombinant human MIA-2 is a 101 amino acid, 11.5 kDa protein comprising the MIA homologous N-terminal region of the full length MIA-2 protein.