MEC (CCL28)
MEC is a secreted CC chemokine expressed primarily by epithelial cells of the bronchioles, salivary gland, mammary gland and colon. MEC signals through the CCR10 receptor and chemoattracts resting CD4, CD8 T-cells and eosinophils. MEC contains six cysteines including the four highly conserved cysteine residues present in CC chemokines. Recombinant murine MEC is a 12.6 kDa protein containing 111 amino acid residues.
Product Specifications
Synonyms
Ccl28; MEC; CCK1; Scya28
NCBI Gene ID
56838
UniProt
Q9JIL2
Accession Number
NP_064675.1
Accession Number mRNA
NM_020279
Chromosomal Location
13; 13
Reactivity
Mouse
Cross Reactivity
Human, Mouse
Sequence
SEAILPMASS CCTEVSHHVS GRLLERVSSC SIQRADGDCD LAAVILHVKR RRICISPHNR TLKQWMRASE VKKNGRENVC SGKKQPSRKD RKGHTTRKHR TRGTHRHEAS R
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to chemoattract murine lymphocytes using a concentration range of 1.0-10.0 ng/ml.
Length
111
Form
Lyophilized
Molecular Weight
12.6 kDa
Host or Source
E. coli
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