MEC (CCL28)
MEC is a secreted CC chemokine expressed primarily by epithelial cells of the bronchioles, salivary glad, mammary gland and colon. MEC signals through the CCR10 receptor and chemoattracts resting CD4, CD8 T-cells and eosinophils. MEC contains six cysteines including the four highly conserved cysteine residues present in CC chemokines. Recombinant human MEC is a 12.3 kDa protein containing 108 amino acid residues.
Product Specifications
Synonyms
CCL28; MEC; CCK1; SCYA28
NCBI Gene ID
56477
UniProt
Q9NRJ3
Accession Number
NP_683513.1
Accession Number mRNA
NM_148672
Chromosomal Location
5p12
Reactivity
Human
Cross Reactivity
Human, Bacteria
Sequence
SEAILPIASS CCTEVSHHIS RRLLERVNMC RIQRADGDCD LAAVILHVKR RRICVSPHNH TVKQWMKVQA AKKNGKGNVC HRKKHHGKRN SNRAHQGKHE TYGHKTPY
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to chemoattract human lymphocytes using a concentration range of 1.0-10.0 ng/ml.
Length
108
Form
Lyophilized
Molecular Weight
12.3 kDa
Host or Source
E. coli
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