MDC (CCL22)
MDC is a CC chemokine that is produced in B cells, macrophages, monocyte-derived dendritic cells, activated NK cells and CD4 T cells. It signals through the CCR4 receptor. MDC chemoattracts monocytes, dendritic cells and NK cells and exerts HIV suppressive activity. The 67 amino acid form of MDC displays reduced chemoattractant activity but retains HIV suppressive activity. Recombinant murine MDC is a 7.8 kDa protein containing 68 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.
Product Specifications
Synonyms
Ccl22; MDC; DCBCK; ABCD-1; Scya22
NCBI Gene ID
20299
UniProt
O88430
Accession Number
NP_033163.1
Accession Number mRNA
NM_009137.2
Chromosomal Location
8 C5; 8
Reactivity
Mouse
Cross Reactivity
Human, Mouse
Sequence
GPYGANVEDS ICCQDYIRHP LPSRLVKEFF WTSKSCRKPG VVLITVKNRD ICADPRQVWV KKLLHKLS
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to chemoattract human activated lymphocytes using a concentration of 10.0-100.0 ng/ml.
Length
68
Form
Lyophilized
Molecular Weight
7.8 kDa
Host or Source
E. coli
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