MDC (67 aa)
MDC is a CC chemokine that is produced in B cells, macrophages, monocyte-derived dendritic cells, activated NK cells and CD4 T cells. It signals through the CCR4 receptor. MDC chemoattracts monocytes, dendritic cells and NK cells and exerts HIV suppressive activity. The 67 amino acid form of MDC displays reduced chemoattractant activity but retains HIV suppressive activity. Recombinant human MDC is an 8.0 kDa protein containing 67 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.
Product Specifications
Synonyms
ADAM11; MDC
NCBI Gene ID
4185
UniProt
O75078
Accession Number
NP_002381
Accession Number mRNA
NM_002390
Chromosomal Location
17q21.3
Reactivity
Human
Cross Reactivity
Hamster, Mouse, Human
Sequence
YGANMEDSVC CRDYVRYRLP LRVVKHFYWT SDSCPRPGVV LLTFRDKEIC ADPRVPWVKM ILNKLSQ
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to chemoattract human T cells using a concentration range of 10.0-100.0 ng/ml.
Length
67
Form
Lyophilized
Molecular Weight
8.0 kDa
Host or Source
E. coli
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