M-CSF
Granulocyte/Macrophage Colony-Stimulating Factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. CSF-1 induces cells of the monocyte/macrophage lineage. It plays a role in immunological defenses, bone metabolism, lipoproteins clearance, fertility and pregnancy. Macrophage Colony Stimulating Factor Human Recombinant produced in E. coli is a disulfide linked homodimer, non-glycosylated, polypeptide chain containing 2 x 159 amino acids and having a total molecular mass of 36.8 KD. M-CSF is purified by proprietary chromatographic techniques.
Product Specifications
Synonyms
CSF1; MCSF; CSF-1
NCBI Gene ID
1435
UniProt
P09603
Accession Number
NP_000748.3
Accession Number mRNA
NM_000757
Chromosomal Location
1p21-p13
Reactivity
Human
Cross Reactivity
Monkey, Mouse, Rat, Human
Sequence
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 95% by SDS-PAGE
Bioactivity
The biological activity was determined by the dose-dependent induction of proliferation in NFS60 cells (Murine myeloid Leukemia cell line) .
Length
159
Form
Lyophilized
Buffer
PBS
Reconstitution
Water
Molecular Weight
36.8 kDa
Host or Source
E. coli
N Terminal Sequence
MEEVS
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