MCP-3 (CCL7)
The MCP proteins belong to the CC chemokine family, and signal through CCR2 and, with the exception of MCP-1, other CCR receptors. The MCP proteins chemoattract and activate monocytes, activated T cells, basophils, NK cells, and immature dendritic cells. The MCP family cross- reacts across species. Recombinant murine MCP-3 is an 8.5 kDa protein containing 74 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.
Product Specifications
Synonyms
Ccl7; fic; marc; mcp3; MCP-3; Scya7
NCBI Gene ID
20306
UniProt
Q03366
Accession Number
NP_038682.1
Accession Number mRNA
NM_013654.3
Chromosomal Location
11 C; 11 46.5 cM
Reactivity
Mouse
Cross Reactivity
Mouse, Human
Sequence
QPDGPNASTC CYVKKQKIPK RNLKSYRRIT SSRCPWEAVI FKTKKGMEVC AEAHQKWVEE AIAYLDMKTP TPKP
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to chemoattract Balb/C mouse spleen MNCs using a concentration range of 10.0-100.0 ng/ml.
Length
74
Form
Lyophilized
Molecular Weight
8.5 kDa
Host or Source
E. coli
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