MCP-3 (CCL7)
The MCP proteins belong to the CC chemokine family, and signal through CCR2 and, with the exception of MCP-1, other CCR receptors. The MCP proteins chemoattract and activate monocytes, activated T cells, basophils, NK cells, and immature dendritic cells. The MCP family cross- reacts across species. Recombinant human MCP-3 is a 9.0 kDa protein containing 76 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.
Product Specifications
Synonyms
CCL7; FIC; MARC; MCP3; NC28; MCP-3; SCYA6; SCYA7
NCBI Gene ID
6354
UniProt
P80098
Accession Number
NP_006264
Accession Number mRNA
NM_006273
Chromosomal Location
17q11.2-q12
Reactivity
Human
Cross Reactivity
Hasmter, Monkey, Mouse, Human
Sequence
QPVGINTSTT CCYRFINKKI PKQRLESYRR TTSSHCPREA VIFKTKLDKE ICADPTQKWV QDFMKHLDKK TQTPKL
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to chemoattract BaF3 cells expressing human CCR2 receptor using a concentration range of 300-500 ng/ml.
Length
76
Form
Lyophilized
Molecular Weight
9 kDa
Host or Source
E. coli
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