MCP-1 (MCAF, CCL2)
The MCP proteins belong to the CC chemokine family, and signal through CCR2 and, with the exception of MCP-1, other CCR receptors. The MCP proteins chemoattract and activate monocytes, activated T cells, basophils, NK cells, and immature dendritic cells. The MCP family cross reacts across species. Recombinant human MCP-1 is an 8.6 kDa protein containing 76 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.
Product Specifications
Synonyms
CCL2; HC11; MCAF; MCP1; MCP-1; SCYA2; GDCF-2; SMC-CF; HSMCR30
NCBI Gene ID
6347
UniProt
P13500
Accession Number
NP_002973
Accession Number mRNA
NM_002982
Chromosomal Location
17q11.2-q12
Reactivity
Human
Cross Reactivity
Chicken, Hamster, Monkey, Mouse, Rat, Human, Leech
Sequence
QPDAINAPVT CCYNFTNRKI SVQRLASYRR ITSSKCPKEA VIFKTIVAKE ICADPKQKWV QDSMDHLDKQ TQTPKT
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to chemoattract human monocytes using a concentration range of 10.0-100.0 ng/ml.
Length
76
Form
Lyophilized
Molecular Weight
8.6 kDa
Host or Source
E. coli
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