Leptin antagonist (mutant L39A/D40A/F41A)
Recombinant rat leptin, one polypeptide chain containing 146 amino and additional Ala at N-terminus acids and having a molecular mass of ~ 16 kDa. Recombinant rat leptin was mutated, resulting in L39A/D40A/F41A mutant that was purified by proprietary chromatographic techniques, according to Salomon et al (2006) Protein Expression and PuriWcation 47, 128–136.
Product Specifications
Synonyms
Lep; ob; obese
NCBI Gene ID
25608
UniProt
P50596
Accession Number
NP_037208
Accession Number mRNA
NM_013076
Reactivity
Rat
Cross Reactivity
Rat
Sequence
AVPIHKVQDDTKTLIKTIVTRINDISHTQSVSARQRVTGAAAIPGLHPILSLSKMDQTLAVYQQILTSLPSQNVLQIAHDLENLRDLLHLLAFSKSCSLPQTRGLQKPESLDGVLEASLYSTEVVALSRLQGSLQDILQQLDLSPEC
Assay Protocol
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98.0% as determined by Gel filtration and SDS-PAGE gel.
Bioactivity
Length
146
Form
Lyophilized
Reconstitution
Water
Molecular Weight
16.0 kDa
Host or Source
E. coli
N Terminal Sequence
AVPIQ
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