IP-10 (CXCL10)

IP-10 is a CXC chemokine that signals through the CXCR3 receptor. IP-10 selectively chemoattracts Th1 lymphocytes and monocytes, and inhibits cytokine-stimulated hematopoietic progenitor cell proliferation. Additionally, it is angiostatic and mitogenic for vascular smooth muscle cells. Recombinant human IP-10 is an 8.6 kDa protein consisting of 77 amino acids including the four conserved cysteine residues present in CXC chemokines.

Product Specifications

Synonyms

CXCL10

NCBI Gene ID

3627

UniProt

P02778

Accession Number

NP_001556.2

Accession Number mRNA

NM_001565.3

Chromosomal Location

4q21

Reactivity

Human

Cross Reactivity

Monkey, Mouse, Leech, Human

Sequence

VPLSRTVRCTCISISNQPVNPRSLEKLEIIPASQFCPRVEIIATMKKKGEKRCLNPESKAIKNLLKAVSKERSKRSP

Endotoxin

< 0.1 ng/µg of protein (< 1EU/µg)

Purity

> 98% by SDS-PAGE & HPLC analyses

Bioactivity

Determined by its ability to chemoattract human T-Lymphocytes using a concentration of 10-50 ng/ml.

Length

Form

Lyophilized

Molecular Weight

8.6 kDa

Host or Source

E. coli

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