IL-7

IL-7 is a hematopoietic growth factor which affects primarily early B and T cells. Produced by thymic stromal cells, spleen cells and keratinocytes, IL-7 can also co-stimulate the proliferation of mature T cells in combination with other factors such as ConA and IL-2. Human and murine IL-7 is cross-species reactive. Recombinant murine IL-7 is a 15.0 kDa protein containing 130 amino acid residues.

Product Specifications

Synonyms

Il7; Il-7; hlb368; A630026I06Rik

NCBI Gene ID

16196

UniProt

P10168

Accession Number

NP_032397.1

Accession Number mRNA

NM_008371

Chromosomal Location

3 A1; 3 6.6 cM

Reactivity

Mouse

Cross Reactivity

Mouse, Human

Sequence

MECHIKDKEG KAYESVLMIS IDELDKMTGT DSNCPNNEPN FFRKHVCDDT KEAAFLNRAA RKLKQFLKMN ISEEFNVHLL TVSQGTQTLV NCTSKEEKNV KEQKKNDACF LKRLLREIKT CWNKILKGSI

Endotoxin

< 0.1 ng/µg of protein (< 1EU/µg)

Purity

> 98% by SDS-PAGE & HPLC analyses

Bioactivity

The ED50 as determined by the dose-dependent stimulation of the proliferation of murine 2E8 cells is < 0.2 ng/ml, corresponding to a specific activity of > 5 x 106 units/mg.