IL-5
IL-5 is a hematopoietic growth factor that stimulates the proliferation and activation of eosinophils. Produced by mast cells, T cells, and eosinophils, IL-5 plays an important role in inducing cell-mediated immunity against parasitic infections and certain tumors. Elevated levels of IL-5 lead to Eosinophilia, which may result in the induction of asthma and other allergic diseases. Human and murine IL-5 is cross-species reactive. Recombinant human IL-5 is a 26.0 kDa disulfide-linked homodimeric protein containing two 116 amino acid chains.
Product Specifications
Synonyms
IL5; EDF; TRF; IL-5
NCBI Gene ID
3567
UniProt
P05113
Accession Number
NP_000840.1
Accession Number mRNA
NM_000879
Chromosomal Location
5q31.1
Reactivity
Human
Cross Reactivity
Mouse, Human, Guinea Pig
Sequence
MIPTEIPTSA LVKETLALLS THRTLLIANE TLRIPVPVHK NHQLCTEEIF QGIGTLESQT VQGGTVERLF KNLSLIKKYI DGQKKKCGEE RRRVNQFLDY LQEFLGVMNT EWIIES
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Length
116
Form
Lyophilized
Molecular Weight
26 kDa
Host or Source
E. coli
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