IL-4
Interleukin 4 (IL-4) is a pleiotropic cytokine produced by activated T cells, mast cells, and basophils. It was initially identified as a B cell differentiation factor (BCDF), as well as a B cell stimulatory factor (BSF1) . IL-4 has since been shown to have multiple biological effects on hematopoietic and non-hematopoietic cells, including B and T cells, monocytes, macrophages, mast cells, myeloid and erythroid progenitors, fibroblasts, and endothelial cells. Rat, mouse and human IL-4 are species-specific in their activities.
Product Specifications
Synonyms
Il4; Il4e12
NCBI Gene ID
287287
UniProt
P20096
Accession Number
NP_958427
Accession Number mRNA
NM_201270
Chromosomal Location
10q22
Reactivity
Rat
Cross Reactivity
Mouse, Rat, Human
Sequence
MHGCNDSPLR EIINTLNQVT EKGTPCTEMF VPDVLTATRN TTENELICRA SRVLRKFYFP RDVPPCLKNK SGVLGELRKL CRGVSGLNSL RSCTVNESTL TTLKDFLESL KSILRGKYLQ SCTSMS
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Tested by its ability to suppress LPS-induced TNF-α and MIP-2 production in mouse splenocytes.
Length
126
Form
Lyophilized
Molecular Weight
14 kDa
Host or Source
E. coli
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