IL-4
IL-4 is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. Produced by mast cells, T cells and bone marrow stromal cells, IL-4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells, characterized by their cytokine-secretion profile that includes secretion of IL-4, IL-5, IL-6, IL-10, and IL-13, which favor a humoral immune response. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL-4 production by Th2 cells has been associated with elevated IgE production and allergy. Recombinant human IL-4 is a 14.9 kDa globular protein containing 130 amino acid residues
Product Specifications
Synonyms
IL4; BSF1; IL-4; BCGF1; BSF-1; BCGF-1
NCBI Gene ID
3565
UniProt
P05112
Accession Number
NP_000580
Accession Number mRNA
NM_000589
Chromosomal Location
5q31.1
Reactivity
Human
Cross Reactivity
Human
Sequence
MHKCDITLQEIIKTLNSLTEQKTLCTELTVTDIFAASKNTTEKETFCRAATVLRQFYSHHEKDTRCLGATAQQFHRHKQLIRFLKRLDRNLWGLAGLNSCPVKEANQSTLENFLERLKTIMREKYSKCSS
Assay Protocol
Endotoxin
< 0.1 ng per µg of IL-4
Purity
> 98% by SDS-PAGE
Bioactivity
The ED50 as determined by the dose-dependent stimulation of human TF-1 cells is 0.1-0.5ng/ml.
Length
130
Form
Lyophilized
Buffer
PBS
Reconstitution
Water
Molecular Weight
14.9 kDa
Storage Conditions
Host or Source
E. coli
N Terminal Sequence
MHKCDITL
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