IL-36RA
The IL-1 family is comprised of 11 structurally related ligands, including the recently re-named IL-36RA (IL-1F5), IL-36α (IL-1F6), IL-36β (IL-1F8), and IL-36γ (IL-1F9) . The interaction of IL-36 ligands with the IL-1Rrp2 receptor (IL-1R6) can induce various activities, including dendritic cell maturation and activation. IL-36RA can antagonize the NF-kappaB signaling induced by either IL-36α, -β or -γ by binding to the IL-1Rrp2 receptor in a manner that prevents the initiation of functional signaling. Recombinant human IL-36RA is an E. coli derived 17 kDa protein containing 154 amino acid residues.
Product Specifications
Synonyms
FIL1 delta, IL-1F5, IL-1HY1, IL-1L1, IL-1RP3, IL-1ra homolog 1, IL-1 delta
NCBI Gene ID
26525
UniProt
Q9UBH0
Accession Number
NP_036407.1
Accession Number mRNA
NM_012275.2
Chromosomal Location
2q14
Reactivity
Human
Cross Reactivity
Human
Sequence
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Measured by its ability to inhibit IL-36γ induced IL-6 production by human PBMCs.
Length
154
Form
Lyophilized
Molecular Weight
17 kDa
Host or Source
E. coli
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
![Mouse Monoclonal CD40 Ligand/TNFSF5 Antibody (40804) [PE/Cy5.5]](https://cdn.genprice.uk/genprice/uk/genprice3.webp)
Mouse Monoclonal CD40 Ligand/TNFSF5 Antibody (40804) [PE/Cy5.5]
TNNT2 (Troponin T, Cardiac Muscle, TnTc, Cardiac Muscle Troponin T, cTnT, CMH2, CMPD2, LVNC6, RCM3) (MaxLight 550)
TNNT2 (Troponin T, Cardiac Muscle, TnTc, Cardiac Muscle Troponin T, cTnT, CMH2, CMPD2, LVNC6, RCM3) (MaxLight 550)