IL-31
IL-31 is a T-cell derived cytokine that shares several structural and functional characteristics with IL-6, Oncostatin M, LIF, and Cardiotrophin-1. It signals through a receptor complex comprised of GPL (GP130-like, IL-31RA) and OSMR (Oncostatin M receptor) . GPL/OSMR signaling is a strong activator of STAT3 and STAT5, and can also activate STAT1, Jak1, and Jak2 signaling pathways. IL-31 regulated immune responses have been implicated in skin physiology and inflammatory skin diseases. Recombinant murine IL-31 is a 15.8 kDa protein containing 140 amino acid residues.
Product Specifications
Synonyms
Il31; 1700013B14Rik
NCBI Gene ID
76399
UniProt
Q6EAL8
Accession Number
NP_083870.1
Accession Number mRNA
NM_029594
Chromosomal Location
5 F; 5
Reactivity
Mouse
Cross Reactivity
Mouse
Sequence
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Testing in progress.
Length
140
Form
Lyophilized
Molecular Weight
15.8 kDa
Host or Source
E. coli
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