IL-31
Human IL-31 is a T-cell derived cytokine that shares several structural and functional characteristics with IL-6, Oncostatin M, LIF, and Cardiotrophin-1. It signals through a receptor complex comprised of GPL (GP130-like, IL-31RA) and OSMR (Oncostatin M receptor) . GPL/OSMR signaling is a strong activator of STAT3 and STAT5, and can also activate STAT1, Jak1, and Jak2 signaling pathways. IL-31 regulated immune responses have been implicated in skin physiology and inflammatory skin diseases. Recombinant IL-31 is a 15.8 kDa protein containing 141 amino acid residues.
Product Specifications
Synonyms
IL31; IL-31
NCBI Gene ID
386653
UniProt
Q6EBC2
Accession Number
NP_001014358.1
Accession Number mRNA
NM_001014336.1
Chromosomal Location
12q24.31
Reactivity
Human
Cross Reactivity
Human
Sequence
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Measured by its ability to induce STAT3 activation in human U87 cells.
Length
141
Form
Lyophilized
Molecular Weight
15.8 kDa
Host or Source
E. coli
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