IL-24
IL-24 is a secreted glycoprotein belonging to the IL-10 structural family of cytokines. It is produced by a variety of cell types, including B cells, CD4+ cells, NK cells, lymph node DCs, monocytes, and melanoma cells. IL-24 can signal through the IL20R1/IL20R2 and IL22R1/IL20R2 receptors to initiate a signaling cascade which includes the induction of JAK1/STAT3 phosphorylation. IL-24 is, functionally, a pleiotropic protein but is generally characterized as an anti-cancer cytokine that can selectively inhibit growth of a wide variety of human cancer cells through activities that include the induction of differentiation and apoptosis, and the suppression of angiogenesis and cell proliferation. Recombinant human IL-24 is an 18.9 kDa glycoprotein, containing 161 amino acid residues, including a C-terminal His-tag.
Product Specifications
Synonyms
Interleukin 24; C49A; FISP; MDA7; MOB5; ST16; IL10B
NCBI Gene ID
11009
UniProt
Q13007
Accession Number
NP_006841.1
Accession Number mRNA
NM_006850.3
Chromosomal Location
1q32
Reactivity
Human
Cross Reactivity
Human
Label
His-tag
Sequence
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 95% by SDS-PAGE & HPLC analyses
Bioactivity
Testing in progress.
Length
161
Form
Lyophilized
Molecular Weight
18.9 kDa
Host or Source
CHO cells
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
