IL-2
IL-2 is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions which are essential for the immune response. IL-2 stimulates growth and differentiation of B-cells, NK cells, lymphokine activated killer cells, monocytes, macrophages and oligodendrocytes. Recombinant human IL-2 (modified at the C-terminal end) is a 15.5 kDa protein, containing 156 amino acid residues including one intrachain disulfide bond.
Product Specifications
Synonyms
IL2; IL-2; TCGF; lymphokine
NCBI Gene ID
3558
UniProt
P60568
Accession Number
NP_000577
Accession Number mRNA
NM_000586
Chromosomal Location
4q26-q27
Reactivity
Human
Cross Reactivity
Human
Sequence
Assay Protocol
Endotoxin
< 0.1 ng per µg of IL-2
Purity
> 98% by SDS-PAGE
Bioactivity
The ED50 as determined by the dose-dependent stimulation of proliferation of murine D10G4.1 cells is in the range of 0.1-0.5 ng/ml.
Length
156
Form
Lyophilized
Buffer
50mM acetic acid
Reconstitution
50mM acetic acid
Molecular Weight
15.5 kDa
Storage Conditions
Host or Source
E. coli
N Terminal Sequence
APTSSSTK and MAPTSSST
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