IL-19
IL-19 belongs to the IL-10 family of regulatory cytokines which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences but they are dissimilar in their biological functions. Preliminary data suggests that IL-19 is a proinflammatory cytokine because it up-regulates IL-6 and TNF-alpha and induces apoptosis through TNF-alpha. IL-19 signals through the type I IL-20R. Human and murine IL-19 share 71% amino acid sequence identity. Recombinant human IL-19 is a 17.9 kDa protein containing 153 amino acid residues. In solution IL-19 exists predominantly as a non-disulfide-linked dimer.
Product Specifications
Synonyms
IL19; MDA1; NG.1; ZMDA1; IL-10C
NCBI Gene ID
29949
UniProt
Q9UHD0
Accession Number
NP_715639.1
Accession Number mRNA
NM_153758
Chromosomal Location
1q32.2
Reactivity
Human
Cross Reactivity
Human
Sequence
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 99% by SDS-PAGE & HPLC analysis
Bioactivity
Determined by its ability to activate STAT following receptor-ligand interaction.
Length
153
Form
Lyophilized
Molecular Weight
17.9 kDa
Host or Source
E. coli
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