IL-17E
IL-17E is a disulfide-linked homodimer of two 145 amino acid polypeptide chains. It belongs to the IL-17 family of structurally-related cytokines that share a highly conserved C-terminal region, but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17E stimulated secretion of IL-8, and induces activation of the transcription factor NK-kB in cells that express the IL-17BR receptor. Recombinant human IL-17E is a 33.8 kDa disulfide-linked homodimer of two 145 amino acid polypeptide chains.
Product Specifications
Synonyms
IL25; IL17E
NCBI Gene ID
64806
UniProt
Q9H293
Accession Number
NP_073626.1
Accession Number mRNA
NM_022789
Chromosomal Location
14q11.2
Reactivity
Human
Cross Reactivity
Human
Sequence
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to induce IL-8 in human PBMCs using a concentration range of 10-100ng.
Length
145
Form
Lyophilized
Molecular Weight
33.8 kDa
Host or Source
E. coli
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