IL-17E
IL-17E is a disulfide-linked homodimer of two 145 amino acid polypeptide chains. It belongs to the IL-17 family of structurally-related cytokines that share a highly conserved C-terminal region, but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17E stimulated secretion of IL-8, and induces activation of the transcription factor NK-kB in cells that express the IL-17BR receptor. Recombinant human IL-17E is a 33.8 kDa disulfide-linked homodimer of two 145 amino acid polypeptide chains.
Product Specifications
Synonyms
IL25; IL17E
NCBI Gene ID
64806
UniProt
Q9H293
Accession Number
NP_073626.1
Accession Number mRNA
NM_022789
Chromosomal Location
14q11.2
Reactivity
Human
Cross Reactivity
Human
Sequence
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to induce IL-8 in human PBMCs using a concentration range of 10-100ng.
Length
145
Form
Lyophilized
Molecular Weight
33.8 kDa
Host or Source
E. coli
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Lce3c Mouse shRNA Lentiviral Particle (Locus ID 94060)
VAHTS Maxi Unique Dual Index Primers Set 1 for Illumina (Plate)