IL-17A
The originally described IL-17 protein, now known as IL-17A, is a disulfide linked homodimer, secreted by activated T-cells that act on stromal cells to induce production of proinflammatory and hematopoietic bioactive molecules. Today, IL-17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17A exhibits cross-species bioactivity between human and murine cells. Recombinant murine IL-17A is a 30.0 kDa disulfide-linked homodimer of two 133 amino acid polypeptide chains.
Product Specifications
Synonyms
IL-17, CTLA-8
NCBI Gene ID
16171
UniProt
Q62386
Accession Number
NP_034682.1
Accession Number mRNA
NM_010552.3
Chromosomal Location
1; 1 A
Reactivity
Mouse
Cross Reactivity
Rat, Mouse, Human
Sequence
AAIIPQSSAC PNTEAKDFLQ NVKVNLKVFN SLGAKVSSRR PSDYLNRSTS PWTLHRNEDP DRYPSVIWEA QCRHQRCVNA EGKLDHHMNS VLIQQEILVL KREPESCPFT FRVEKMLVGV GCTCVASIVR QAA
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Measured by its ability to induce IL-6 production by NIH 3T3 cells.
Length
133
Form
Lyophilized
Molecular Weight
30 kDa
Host or Source
E. coli
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